This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
Hematology & Oncology
16 calculators · absolute cell counts, reticulocytes, iron, transfusion, tumor lysis, DIC
This section contains pediatric calculators for hematology and transfusion medicine: absolute neutrophil, lymphocyte and eosinophil count (with CTCAE v5.0 and reference values according to Comans-Bitter 1997), reticulocyte count and reticulocyte production index, Mentzer index, transferrin saturation and the Ganzoni formula. Also included are blood volume, red cell and platelet transfusion (BSH 2016, Davies 2007) as well as scores for tumor lysis syndrome (Cairo-Bishop, Howard 2011), fever and neutropenia (SPOG 2010) and DIC (ISTH). They are intended for interpreting blood count findings and planning transfusions, for example in practice, oncology and hospital. Each calculator states its formula and sources.
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Absolute neutrophil count (ANC)
From leukocytes and the proportion of segmented and band neutrophils – neutropenia grades (classic and CTCAE v5.0) -
Absolute lymphocyte count (ALC)
From leukocytes and lymphocyte proportion – age-related reference values (Comans-Bitter 1997) and CTCAE grades -
Absolute eosinophil count (AEC)
From leukocytes and eosinophil proportion – mild, moderate and severe eosinophilia -
Absolute and corrected reticulocyte count
Reticulocytes in ‰ or % → absolute count and correction for hematocrit (reticulocyte index) -
Reticulocyte production index (RPI)
Corrected reticulocyte count divided by the hematocrit-dependent maturation time – < 2 hypoproliferative, > 3 adequate response -
Mentzer index
MCV / red blood cell count: > 13 iron deficiency, < 13 thalassemia – screening in microcytic anemia -
Transferrin saturation
Serum iron / iron-binding capacity (or transferrin × 1.41) × 100 – with CALIPER reference intervals by age -
Ganzoni formula – cumulative iron requirement
Weight × (target Hb − actual Hb) × 2.4 + iron stores; pediatric < 35 kg target 13 g/dl and 15 mg/kg stores -
Blood volume by age
Estimated circulating blood volume (ml/kg by age group) and maximum tolerable blood loss -
Packed red cell transfusion volume
Volume for a desired Hb increase according to BSH 2016 (factor 3–5), Davies 2007 (3/Hct), and the German Medical Association (Bundesärztekammer) (3 ml/kg per g/dl) -
Expected Hb rise after transfusion
From volume and weight: German Medical Association (1 g/dl per 3 ml/kg), Davies (ml/kg × Hct / 3) and BSH inverse formula -
Platelet transfusion – dose and CCI
10–20 ml/kg below 15 kg, from 15 kg one apheresis concentrate (BSH 2016); response monitoring with the corrected count increment (CCI) -
Tumor lysis syndrome according to Cairo-Bishop (modified by Howard 2011)
Laboratory TLS: at least two of uric acid ≥ 8 mg/dl, potassium ≥ 6 mmol/l, phosphate ≥ 6.5 mg/dl (children), calcium ≤ 7 mg/dl – clinical TLS with creatinine, arrhythmia, seizure -
Fever and neutropenia – risk score (SPOG 2010)
Four weighted variables (chemotherapy, Hb, leukocytes, platelets), collected at reassessment after 8–24 hours – from 9 points increased risk of serious complications; with Rackoff classification -
ISTH DIC score
Platelets, fibrin markers, prothrombin time, fibrinogen (0–8 points) – ≥ 5 compatible with overt DIC (Taylor 2001) -
Anemia according to WHO 2024: hemoglobin cut-offs for children and adolescents
Hemoglobin threshold and severity by age, sex and altitude of residence, 6 months to 17 years (WHO guideline 2024)
Frequently asked questions
How do I calculate the absolute neutrophil count?
The Absolute Neutrophil Count (ANC) calculator computes it from the leukocytes and the proportion of segmented and band neutrophils, and classifies the grades of neutropenia both classically and according to CTCAE v5.0.
How do I calculate the packed red cell transfusion volume in children?
The red cell transfusion volume calculator determines the volume for a desired Hb increase according to BSH 2016 (factor 3–5), Davies 2007 (3/Hct) and the German Medical Association (Bundesärztekammer). This allows the results of the three sources to be compared.
How do I calculate iron requirement with the Ganzoni formula?
The Ganzoni formula calculates the cumulative iron requirement as weight × (target Hb − actual Hb) × 2.4 plus storage iron. In pediatrics, below 35 kg a target Hb of 13 g/dl and a storage iron of 15 mg/kg apply.