This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.

• Absolute neutrophil count (ANC)

  From leukocytes and the proportion of segmented and band neutrophils – neutropenia grades (classic and CTCAE v5.0)

• Absolute lymphocyte count (ALC)

  From leukocytes and lymphocyte proportion – age-related reference values (Comans-Bitter 1997) and CTCAE grades

• Absolute eosinophil count (AEC)

  From leukocytes and eosinophil proportion – mild, moderate and severe eosinophilia

• Absolute and corrected reticulocyte count

  Reticulocytes in ‰ or % → absolute count and correction for hematocrit (reticulocyte index)

• Reticulocyte production index (RPI)

  Corrected reticulocyte count divided by the hematocrit-dependent maturation time – < 2 hypoproliferative, > 3 adequate response

• Mentzer index

  MCV / red blood cell count: > 13 iron deficiency, < 13 thalassemia – screening in microcytic anemia

• Transferrin saturation

  Serum iron / iron-binding capacity (or transferrin × 1.41) × 100 – with CALIPER reference intervals by age

• Ganzoni formula – cumulative iron requirement

  Weight × (target Hb − actual Hb) × 2.4 + iron stores; pediatric < 35 kg target 13 g/dl and 15 mg/kg stores

• Blood volume by age

  Estimated circulating blood volume (ml/kg by age group) and maximum tolerable blood loss

• Packed red cell transfusion volume

  Volume for a desired Hb increase according to BSH 2016 (factor 3–5), Davies 2007 (3/Hct), and the German Medical Association (Bundesärztekammer) (3 ml/kg per g/dl)

• Expected Hb rise after transfusion

  From volume and weight: German Medical Association (1 g/dl per 3 ml/kg), Davies (ml/kg × Hct / 3) and BSH inverse formula

• Platelet transfusion – dose and CCI

  10–20 ml/kg below 15 kg, from 15 kg one apheresis concentrate (BSH 2016); response monitoring with the corrected count increment (CCI)

• Tumor lysis syndrome according to Cairo-Bishop (modified by Howard 2011)

  Laboratory TLS: at least two of uric acid ≥ 8 mg/dl, potassium ≥ 6 mmol/l, phosphate ≥ 6.5 mg/dl (children), calcium ≤ 7 mg/dl – clinical TLS with creatinine, arrhythmia, seizure

• Fever and neutropenia – risk score (SPOG 2010)

  Four weighted variables (chemotherapy, Hb, leukocytes, platelets) – from 9 points increased risk of serious complications; with Rackoff classification

• ISTH DIC score

  Platelets, fibrin markers, prothrombin time, fibrinogen (0–8 points) – ≥ 5 compatible with overt DIC (Taylor 2001)

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