This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
Tumor lysis syndrome according to Cairo-Bishop (modified by Howard 2011)
Laboratory TLS: at least two of uric acid ≥ 8 mg/dl, potassium ≥ 6 mmol/l, phosphate ≥ 6.5 mg/dl (children), calcium ≤ 7 mg/dl – clinical TLS with creatinine, arrhythmia, seizure
Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.
Frequently asked questions
Tumor lysis syndrome according to Cairo-Bishop (modified by Howard 2011): What does this calculator compute?
Checks the Cairo-Bishop criteria for laboratory tumor lysis syndrome (at least two abnormalities of uric acid, potassium, phosphate and corrected calcium within 3 days before to 7 days after the start of therapy) and for clinical TLS (additionally creatinine rise, cardiac arrhythmia or seizure) in the modification by Howard 2011: without the 25 % change criterion of the original; the clinical grading 0–5 according to Cairo-Bishop is not calculated.
Tumor lysis syndrome according to Cairo-Bishop (modified by Howard 2011): Which sources is this calculator based on?
Cairo MS, Bishop M: Tumour lysis syndrome: new therapeutic strategies and classification (Br J Haematol 127:3–11) (2004); Howard SC, Jones DP, Pui CH: The tumor lysis syndrome (N Engl J Med 364:1844–1854) (2011)