This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
Levothyroxine Starting Dose in Congenital Hypothyroidism
Starting dose of L-thyroxine for newborns with congenital hypothyroidism by pretreatment fT4 (ESPE/ENDO-ERN 2020–2021)
Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.
Frequently asked questions
Levothyroxine Starting Dose in Congenital Hypothyroidism: What does this calculator compute?
Starting dose of levothyroxine (L-thyroxine) in congenital hypothyroidism according to the consensus 2020–2021 (van Trotsenburg, ESPE): severe form (fT4 below 5 pmol/l) 10–15 µg/kg per day, mild form (fT4 above 10 pmol/l with elevated TSH) about 10 µg/kg, fT4 within the reference range 5–10 µg/kg; central hypothyroidism mild 5–10 µg/kg. For fT4 from 5 to 10 pmol/l the guideline gives no specific dose.
Levothyroxine Starting Dose in Congenital Hypothyroidism: Which sources is this calculator based on?
van Trotsenburg P, Stoupa A, Léger J, et al.: Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update – An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology (Thyroid 31:387–419) (2021)