This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
HOMA-IR
Insulin resistance from fasting glucose and insulin – study-specific cut-offs for obese children by pubertal status and sex (Kurtoğlu 2010, Keskin 2005); no universal threshold
Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.
Frequently asked questions
HOMA-IR: What does this calculator compute?
Calculates the HOMA-IR (Matthews 1985: glucose × insulin / 22.5 or / 405) and compares it with the ROC cut-offs for obese children and adolescents (Kurtoğlu 2010, obese children: prepubertal 2.67 ♂ / 2.22 ♀, pubertal 5.22 ♂ / 3.82 ♀; Keskin 2005, obese adolescents: 3.16). There is no universal pediatric or adult cut-off; the frequently cited value 2.5 is population-dependent.
HOMA-IR: Which sources is this calculator based on?
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man (Diabetologia 28:412–419) (1985); Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M: Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods (J Clin Res Pediatr Endocrinol 2:100–106) (2010); Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C: Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents (Pediatrics 115:e500–e503) (2005); Knopp JL, Holder-Pearson L, Chase JG: Insulin Units and Conversion Factors: A Story of Truth, Boots, and Faster Half-Truths (J Diabetes Sci Technol 13:597–600) (2019); Roche Diagnostics: Elecsys Insulin – method sheet (cobas e 411/e 601): “µU/mL × 6,945 = pmol/L” (2022)