This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
Syndromes
6 calculators · Down syndrome (Zemel 2015), Noonan syndrome (Cappa 2024), Turner syndrome, achondroplasia
Here you will find syndrome-specific growth references for children and adolescents. Included are the US growth charts for Down syndrome (Zemel 2015, 0–36 months and 2–20 years), the Turner reference chart (Lyon 1985) with final height prediction, the charts for Noonan syndrome (Cappa 2024, with LMS parameters according to Chou 2025) and the achondroplasia reference of the CLARITY study (Hoover-Fong 2021). The calculators provide percentiles and z-scores and are intended for follow-up assessment by healthcare professionals when standard charts are not appropriate. Each calculator states its formula and sources.
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Down syndrome 0–36 months (Zemel 2015)
Weight, length, head circumference and weight-for-length -
Down syndrome 2–20 years (Zemel 2015)
Weight, height, head circumference and BMI -
Turner syndrome (Lyon 1985)
Height 1–20 years on the Turner reference curve -
Noonan syndrome (Cappa 2024)
Height, weight, BMI and growth velocity -
Turner syndrome – SDS and final height prediction
Height SDS on the Turner curve (Lyon 1985) and final height from the achieved SDS or the regression of Lyon -
Achondroplasia – growth reference (CLARITY 2021)
Z-scores for length/height, weight, head circumference and weight-for-height in achondroplasia (data up to 18 years)
Frequently asked questions
Are there percentile charts for children with Down syndrome?
Yes. The Down syndrome 0–36 months and 2–20 years calculators use the US growth charts according to Zemel 2015 and provide percentiles and z-scores for weight, length or height, head circumference, BMI and weight-for-length.
How do I estimate final height in Turner syndrome?
The Turner Syndrome – SDS and Final Height Prediction calculator places height on the Turner chart (Lyon 1985) and estimates final height without growth hormone therapy, by maintaining the SDS (142.9 + SDS × 6.7 cm) or with the Lyon regression.
Which growth reference exists for achondroplasia?
The Achondroplasia – Growth Reference calculator uses the US natural history study CLARITY (Hoover-Fong 2021). It calculates z-scores for length/height, weight, head circumference (0–5 years) and weight-for-height using the asymmetric standard deviations of the publication.