This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.

Noonan syndrome (Cappa 2024)

Height, weight, BMI and growth velocity

Child

Sex

male female

Gestational age at birth (optional, preterm infants)

Age

Birth and measurement date Age directly

Date of birth

Measurement date

Years

Months

Weeks

Days

Use corrected age – for preterm infants the weeks until term are subtracted (up to an age of 24 months)

Measured values

Height (standing) (cm)

Weight (kg)

Growth velocity (cm/year)

Decimal separator comma or period. Empty fields are skipped.

Reset Reference range: 0–18 years

About this calculator

Percentiles and z-scores for height, weight, BMI and growth velocity (cm/year, from two height measurements) in Noonan syndrome according to Cappa 2024 (0–18 years) – with the LMS parameters re-estimated by Chou 2025, because an Expression of Concern exists for the published BMI values of the boys and Chou found further discrepancies.

In preterm infants, if a gestational age is given, age is corrected up to month 24 of life for the missing weeks up to 40+0. The z-score (SDS) describes the deviation from the median in standard deviations; the percentile the proportion of the reference population with a smaller value.

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Reference and license

Noonan syndrome (Cappa 2024) – 0–18 years.
Cappa M, d'Aniello F, Digilio MC, et al. Noonan syndrome growth charts and genotypes: 15-year longitudinal single-centre study. Horm Res Paediatr 2024 (doi:10.1159/000540092). LMS-Parameter: Chou JH. Correction of LMS parameter errors in published Noonan syndrome growth charts. medRxiv 2025.07.29.25332354. License: publication CC BY-NC (Karger); corrected LMS parameters CC BY 4.0 (Chou 2025, preprint). Source
An official Expression of Concern exists for the male BMI LMS parameters of supplementary table S1h (Karger 2026). Chou 2025 additionally found discrepancies in boys' weight and in girls' growth velocity and re-estimated all LMS parameters from the published percentile values; these values are used here – a preprint, not an official author correction. The curves apply to 0–18 years: for 18–20 years the data were insufficient according to the authors.

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Note

Calculation aid for healthcare professionals. Percentiles and z-scores describe the position of a measured value in the reference population; clinical assessment remains with the treating physician.

Review date of the German original: 2026-11-05 · Methodology

Frequently asked questions

Noonan syndrome (Cappa 2024): What does this calculator compute?

Noonan syndrome (Cappa 2024): Which sources is this calculator based on?

Cappa M, d'Aniello F, Digilio MC, et al. Noonan syndrome growth charts and genotypes: 15-year longitudinal single-centre study. Horm Res Paediatr 2024 (doi:10.1159/000540092). LMS-Parameter: Chou JH. Correction of LMS parameter errors in published Noonan syndrome growth charts. medRxiv 2025.07.29.25332354.