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This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.

SLEDAI-2K

24 weighted descriptors (8/4/2/1) of lupus activity in the last 10 days (Gladman 2002)

Weight 8
new onset; metabolic, infectious or drug-related causes excluded
severe disturbance of reality perception with impaired daily functioning; uremia and drugs excluded
altered mental status with impaired orientation, memory or intellect, rapid onset, fluctuating, plus ≥ 2 of: perceptual disturbance, incoherent speech, sleep disturbance, change in psychomotor activity
retinal changes of SLE (cotton-wool spots, hemorrhages, serous exudates, optic neuritis); hypertension, infection, drugs excluded
new-onset sensory or motor neuropathy of a cranial nerve
severe, persistent headache, also migraine-like, unresponsive to opioid analgesics
new onset; atherosclerosis excluded
Ulceration, gangrene, painful finger nodules, periungual infarcts, splinter hemorrhages or biopsy/angiography evidence
Weight 4
≥ 2 joints with pain and signs of inflammation (tenderness, swelling or effusion)
proximal muscle pain/weakness with elevated CK/aldolase, EMG changes or biopsy
Hemoglobin-granular or red blood cell casts
> 5 erythrocytes/high-power field; stone, infection or other cause excluded
> 0.5 g/24 h
> 5 leukocytes/high-power field; infection excluded
Weight 2
inflammatory exanthem
abnormal, patchy or diffuse hair loss
oral or nasal ulcerations
pleuritic chest pain with rub, effusion or pleural thickening
Pericardial pain with at least one of: rub, effusion, ECG or echo confirmation
CH50, C3 or C4 below the laboratory's lower limit
Anti-dsDNA (Farr assay) above the laboratory's normal range
Weight 1
> 38 °C; infectious cause excluded
< 100 G/l; drug-induced cause excluded
< 3 G/l; drug-induced cause excluded

Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.