Log in
Professional accountDoctors and healthcare professionals Eltern-Kind-Passwith ID Austria – coming soon
Register
Create professional accountDoctors and healthcare professionals Eltern-Kind-Passwith ID Austria – coming soon

This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.

SLEDAI-2K

24 weighted descriptors (8/4/2/1) of lupus activity in the last 10 days (Gladman 2002)

Weight 8
new onset; metabolic, infectious or drug-related causes excluded
severe disturbance of reality perception with impaired daily functioning; uremia and drugs excluded
altered mental status with impaired orientation, memory or intellect, rapid onset, fluctuating, plus ≥ 2 of: perceptual disturbance, incoherent speech, sleep disturbance, change in psychomotor activity
retinal changes of SLE (cotton-wool spots, hemorrhages, serous exudates, optic neuritis); hypertension, infection, drugs excluded
new-onset sensory or motor neuropathy of a cranial nerve
severe, persistent headache, also migraine-like, unresponsive to opioid analgesics
new onset; atherosclerosis excluded
Ulceration, gangrene, painful finger nodules, periungual infarcts, splinter hemorrhages or biopsy/angiography evidence
Weight 4
≥ 2 joints with pain and signs of inflammation (tenderness, swelling or effusion)
proximal muscle pain/weakness with elevated CK/aldolase, EMG changes or biopsy
Hemoglobin-granular or red blood cell casts
> 5 erythrocytes/high-power field; stone, infection or other cause excluded
> 0.5 g/24 h
> 5 leukocytes/high-power field; infection excluded
Weight 2
inflammatory exanthem
abnormal, patchy or diffuse hair loss
oral or nasal ulcerations
pleuritic chest pain with rub, effusion or pleural thickening
Pericardial pain with at least one of: rub, effusion, ECG or echo confirmation
CH50, C3 or C4 below the laboratory's lower limit
Anti-dsDNA (Farr assay) above the laboratory's normal range
Weight 1
> 38 °C; infectious cause excluded
< 100 G/l; drug-induced cause excluded
< 3 G/l; drug-induced cause excluded

Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.

Frequently asked questions

SLEDAI-2K: What does this calculator compute?

SLEDAI-2K (Gladman 2002): 24 descriptors with weights of 8, 4, 2 or 1, scored if present at the time of the visit or in the preceding 10 days; total with a widely used orientation classification that is not part of the score (0 / 1–5 / 6–10 / 11–19 / ≥ 20).

SLEDAI-2K: Which sources is this calculator based on?

Gladman DD, Ibañez D, Urowitz MB: Systemic Lupus Erythematosus Disease Activity Index 2000 (J Rheumatol 29:288–291) – Table 2 (2002); Uribe AG, Vilá LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcón GS: The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index, and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus (J Rheumatol 31:1934–1940) (2004)