This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
Corrected phenytoin level
Correct total level in hypoalbuminemia by Sheiner-Tozer (with variant for renal insufficiency)
Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.
Frequently asked questions
Corrected phenytoin level: What does this calculator compute?
Corrects the measured total phenytoin level for low albumin using the Sheiner-Tozer equation (level ÷ (0.2 × albumin g/dl + 0.1); with GFR < 20 ml/min factor 0.1) and classifies it within the therapeutic range 10–20 µg/ml; albumin in g/dl or g/l.
Corrected phenytoin level: Which sources is this calculator based on?
Kiang TK, Ensom MH: A comprehensive review on the predictive performance of the Sheiner-Tozer and derivative equations for the correction of phenytoin concentrations (Ann Pharmacother 50:311–325) (2016); Sheiner LB, Tozer TN: Clinical pharmacokinetics: the use of plasma concentrations of drugs. In: Melmon KL, Morrelli HF (eds.), Clinical Pharmacology: Basic Principles in Therapeutics, edition 2, Macmillan 1978 (1978)