This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.

BRUE 2.0 / Risk after a BRUE: serious underlying diagnosis and event recurrence

Two logistic models after a BRUE (Nama 2022): risk of a serious underlying diagnosis and of event recurrence, with the results of the Canadian validation 2024

Infant

Age

History

Prior similar event before this presentation

Multiple events or event clusters before this presentation

Abnormal medical history (e.g., prior hospital admission, urinary tract infection)

Prematurity: born before 32 weeks, or born at 32 to 38 weeks and still under 45 weeks corrected

Event

Color change (cyanosis or pallor)

Abnormal breathing pattern (absent, reduced or irregular breathing)

Tone change (markedly increased or decreased muscle tone)

Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.

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Sources

Risk Prediction After a Brief Resolved Unexplained Event (Hosp Pediatr 12:772–785) Nama N, Hall M, Neuman M, Sullivan E, et al., Tieder JS; Brief Resolved Unexplained Event Research and Quality Improvement Network, 2022. Derivation (PMID 35965279), 3283 infants from 15 US children's hospitals; full text not read
External Validation of Brief Resolved Unexplained Events Prediction Rules for Serious Underlying Diagnosis (JAMA Pediatr 179:188–196) Nama N, Shen Y, Bone JN, et al.; Canadian BRUE Collaboration (C-BRUE-C) and Canadian Paediatric Inpatient Research Network (PIRN), 2024. External validation (PMC11791710), 1042 infants from Canada; supplement 1, eTable 4 read

Related calculators

Note

Calculation aid for healthcare professionals. Clinical assessment remains with the treating physician.

Review date of the German original: 2026-11-08 · Methodology

For parents (in German): Fever in children (kinderarzt.net)

Frequently asked questions

BRUE 2.0 / Risk after a BRUE: serious underlying diagnosis and event recurrence: What does this calculator compute?

BRUE 2.0 (Nama 2022, Hospital Pediatrics) estimates two risks after a BRUE (brief resolved unexplained event) in infants under 1 year: a serious underlying diagnosis (from age in days, a prior similar event and abnormal medical history) and event recurrence (from prematurity, prior and multiple events, color change, breathing pattern and tone change). Coefficients from eTable 4 of the Canadian validation (JAMA Pediatrics 2024). The models discriminate only moderately (AUC 0.60 and 0.67) and complement the AAP classification of 2016.

BRUE 2.0 / Risk after a BRUE: serious underlying diagnosis and event recurrence: Which sources is this calculator based on?

Nama N, Hall M, Neuman M, Sullivan E, et al., Tieder JS; Brief Resolved Unexplained Event Research and Quality Improvement Network: Risk Prediction After a Brief Resolved Unexplained Event (Hosp Pediatr 12:772–785) (2022); Nama N, Shen Y, Bone JN, et al.; Canadian BRUE Collaboration (C-BRUE-C) and Canadian Paediatric Inpatient Research Network (PIRN): External Validation of Brief Resolved Unexplained Events Prediction Rules for Serious Underlying Diagnosis (JAMA Pediatr 179:188–196) (2024)