This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.
Renal dose adjustment
Dose or interval according to Dettli from GFR and extrarenal elimination fraction Q0
Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.
Frequently asked questions
Renal dose adjustment: What does this calculator compute?
Adjusts a maintenance dose to renal function (Dettli): Q = Q0 + (1 − Q0) × GFR/100 with Q0 as the extrarenally eliminated fraction from the summary of product characteristics – as a dose reduction at the same interval or as an interval extension at the same dose; loading doses remain unchanged.
Renal dose adjustment: Which sources is this calculator based on?
Dettli L: Drug dosage in renal disease (Clin Pharmacokinet 1:126–134) (1976); Scholz W: Dose adjustments in renal failure: does the Dettli formula need an update moving away from linearity? (Austin J Pharmacol Ther 12:1192) (2024); Munar MY, Singh H: Drug dosing adjustments in patients with chronic kidney disease (Am Fam Physician 75:1487–1496) (2007)