This version was machine-translated from German and has not been medically reviewed. The authoritative version is the German version.

Paracetamol poisoning: nomogram line

Serum paracetamol 4–24 hours after a single ingestion: at or above the treatment line 150 mg/l or the UK line 100 mg/l?

Calculation aid for healthcare professionals: the calculator reproduces what the sources cited assign to the inputs. Clinical assessment and every treatment decision remain with the treating physician. Inputs and results are not stored.

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Sources

Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand (Med J Aust 212:175–183) Chiew AL, Reith D, Pomerleau A, Wong A, Isoardi KZ, Soderstrom J, Buckley NA, 2020. Consensus guideline, text read (nomogram only as an image)
Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement (JAMA Netw Open 6:e2327739) Dart RC, et al., 2023. Consensus guideline, open access, read
Treating paracetamol overdose with intravenous acetylcysteine: new guidance (Drug Safety Update) Medicines and Healthcare products Regulatory Agency (MHRA), Commission on Human Medicines, 2012. Official notice, read
Acetaminophen poisoning and toxicity (Pediatrics 55:871–876) Rumack BH, Matthew H, 1975. Original paper of the nomogram – not read, only cited
Acetaminophen (CID 1983) – Molecular Weight PubChem, National Library of Medicine, 2026. Substance database, molar mass 151.16 g/mol
Poison information centers (poison control centers) in Germany, Austria and Switzerland Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL), 2026. List of the authority, read on 2026-11-08
Tox Info Suisse – emergency number Tox Info Suisse, Zurich, 2026. Website, read on 2026-11-08

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Note

Calculation aid for healthcare professionals. Clinical assessment remains with the treating physician.

Review date of the German original: 2026-11-08 · Methodology

Frequently asked questions

Paracetamol poisoning: nomogram line: What does this calculator compute?

Compares the serum paracetamol concentration with the treatment line of the nomogram (Rumack-Matthew): 150 mg/l at 4 hours, then halving every 4 hours, valid from 4 to 24 hours after a single acute ingestion. In addition the UK line with 100 mg/l at 4 hours (MHRA 2012). Input in mg/l or µmol/l. No acetylcysteine regimen – determine the dose with the poison information center.

Paracetamol poisoning: nomogram line: Which sources is this calculator based on?

Chiew AL, Reith D, Pomerleau A, Wong A, Isoardi KZ, Soderstrom J, Buckley NA: Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand (Med J Aust 212:175–183) (2020); Dart RC, et al.: Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement (JAMA Netw Open 6:e2327739) (2023); Medicines and Healthcare products Regulatory Agency (MHRA), Commission on Human Medicines: Treating paracetamol overdose with intravenous acetylcysteine: new guidance (Drug Safety Update) (2012); Rumack BH, Matthew H: Acetaminophen poisoning and toxicity (Pediatrics 55:871–876) (1975); PubChem, National Library of Medicine: Acetaminophen (CID 1983) – Molecular Weight (2026); Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL): Giftinformationszentren (Giftnotrufzentralen) in Deutschland, Österreich und der Schweiz (2026); Tox Info Suisse, Zürich: Tox Info Suisse – Notfallnummer (2026)